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MGP001354

UniProt Annotations

Entry Information
Gene Nameglutathione S-transferase mu 3 (brain)
Protein EntryGSTM3_HUMAN
UniProt IDP21266
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=1.1 mM for 1-chloro-2,4-dinitrobenzene {ECO:0000269|PubMed:10587441}; KM=0.084 mM for glutathione {ECO:0000269|PubMed:10587441};
Catalytic ActivityRX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:10587441}.
FunctionConjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers. {ECO:0000269|PubMed:10587441}.
InteractionSelf; NbExp=4; IntAct=EBI-350350, EBI-350350;
PtmThe N-terminus is blocked.
SimilarityBelongs to the GST superfamily. Mu family. {ECO:0000305}.
SimilarityContains 1 GST C-terminal domain. {ECO:0000305}.
SimilarityContains 1 GST N-terminal domain. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000269|PubMed:10587441}.
Tissue SpecificityTestis and brain.
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