MGP Database

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MGP001357

Ontology/Pathway Information

Entrez Gene ID2950
Gene Nameglutathione S-transferase pi 1
Gene Symbol GSTP1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 TAS:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005615 IDA:UniProtKBCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005622 IDA:BHF-UCLCintracellular
GO:0005739 IDA:HPACmitochondrion
GO:0005634 IEA:UniProtKB-SubCellCnucleus
GO:0005886 IDA:HPACplasma membrane
GO:0097057 IDA:BHF-UCLCTRAF2-GSTP1 complex
GO:0031982 IDA:UniProtKBCvesicle
GO:0035731 IDA:BHF-UCLFdinitrosyl-iron complex binding
GO:0004364 IDA:UniProtKBFglutathione transferase activity
GO:0008432 ISS:BHF-UCLFJUN kinase binding
GO:0019207 ISS:BHF-UCLFkinase regulator activity
GO:0070026 NAS:BHF-UCLFnitric oxide binding
GO:0035730 IDA:BHF-UCLFS-nitrosoglutathione binding
GO:0071222 ISS:BHF-UCLPcellular response to lipopolysaccharide
GO:0007417 TAS:ProtIncPcentral nervous system development
GO:0035726 ISS:BHF-UCLPcommon myeloid progenitor cell proliferation
GO:1901687 TAS:ReactomePglutathione derivative biosynthetic process
GO:0006749 IDA:UniProtKBPglutathione metabolic process
GO:0002674 NAS:BHF-UCLPnegative regulation of acute inflammatory response
GO:0043066 TAS:UniProtKBPnegative regulation of apoptotic process
GO:0009890 IDA:BHF-UCLPnegative regulation of biosynthetic process
GO:0070373 IDA:BHF-UCLPnegative regulation of ERK1 and ERK2 cascade
GO:2001237 IDA:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway
GO:0048147 ISS:BHF-UCLPnegative regulation of fibroblast proliferation
GO:0043124 ISS:BHF-UCLPnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032691 IDA:BHF-UCLPnegative regulation of interleukin-1 beta production
GO:0043508 IDA:BHF-UCLPnegative regulation of JUN kinase activity
GO:0070664 ISS:BHF-UCLPnegative regulation of leukocyte proliferation
GO:0043409 NAS:BHF-UCLPnegative regulation of MAPK cascade
GO:0043407 IDA:BHF-UCLPnegative regulation of MAP kinase activity
GO:0071638 IDA:BHF-UCLPnegative regulation of monocyte chemotactic protein-1 production
GO:0051771 IDA:BHF-UCLPnegative regulation of nitric-oxide synthase biosynthetic process
GO:0006469 IDA:BHF-UCLPnegative regulation of protein kinase activity
GO:0032873 ISS:BHF-UCLPnegative regulation of stress-activated MAPK cascade
GO:0010804 IC:BHF-UCLPnegative regulation of tumor necrosis factor-mediated signaling pathway
GO:0032720 IDA:BHF-UCLPnegative regulation of tumor necrosis factor production
GO:0035732 NAS:BHF-UCLPnitric oxide storage
GO:0032930 ISS:BHF-UCLPpositive regulation of superoxide anion generation
GO:0070372 ISS:BHF-UCLPregulation of ERK1 and ERK2 cascade
GO:0032872 ISS:BHF-UCLPregulation of stress-activated MAPK cascade
GO:0000302 ISS:BHF-UCLPresponse to reactive oxygen species
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006805 IDA:UniProtKBPxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13433Biological oxidations
REACT_120956Cellular responses to stress
REACT_268587Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
REACT_268321Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
REACT_268129Defective GGT1 causes Glutathionuria (GLUTH)
REACT_267887Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
REACT_268063Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
REACT_268256Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
REACT_267818Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
REACT_268027Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
REACT_268058Defective UGT1A1 causes hyperbilirubinemia
REACT_268618Defective UGT1A4 causes hyperbilirubinemia
REACT_264249Detoxification of Reactive Oxygen Species
REACT_116125Disease
REACT_6926Glutathione conjugation
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_6959Phase II conjugation
SMP Pathway Links
SMP IDDescription
SMP00640Acetaminophen Metabolism Pathway
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