MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001357

UniProt Annotations

Entry Information
Gene Nameglutathione S-transferase pi 1
Protein EntryGSTP1_HUMAN
UniProt IDP09211
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityRX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:1540159, ECO:0000269|PubMed:1567427, ECO:0000269|PubMed:8433974}.
FunctionConjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21668448}.
InteractionP30041:PRDX6; NbExp=2; IntAct=EBI-353467, EBI-2255129; Q12933:TRAF2; NbExp=5; IntAct=EBI-353467, EBI-355744;
SimilarityBelongs to the GST superfamily. Pi family. {ECO:0000305}.
SimilarityContains 1 GST C-terminal domain. {ECO:0000305}.
SimilarityContains 1 GST N-terminal domain. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:19269317}. Mitochondrion {ECO:0000269|PubMed:19269317}. Nucleus {ECO:0000269|PubMed:19269317}. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.
SubunitHomodimer. Interacts with CDK5. {ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9012673}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gstp1/";
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GSTP1";
  logo