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MGP001360

Record overview

MGPD IDMGP001360
Gene ID2954
SpeciesHomo sapiens (Human)
Gene Nameglutathione S-transferase zeta 1
Gene Symbol GSTZ1
SynonymsMAI; MAAI; GSTZ1-1;
Alternate namesmaleylacetoacetate isomerase; S-(hydroxyalkyl)glutathione lyase; glutathione S-alkyltransferase; glutathione S-aralkyltransferase; glutathione S-aryltransferase; glutathione transferase zeta 1; maleylacetone isomerase;
Chromosome14
Map Location14q24.3
EC Number5.2.1.2
SummaryThis gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for GSTZ1

Proteins

maleylacetoacetate isomerase isoform 1
Refseq ID:NP_665877
Protein GI:22202624
UniProt ID:O43708
mRNA ID:NM_145870
Length:216
RefSeq Status:
MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQVPTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVR
MISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQ
VSHPCRQPDTPTELRA
 
maleylacetoacetate isomerase isoform 2
Refseq ID:NP_665878
Protein GI:194440732
UniProt ID:O43708
mRNA ID:NM_145871
Length:174
RefSeq Status:
MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQVPTLKIDGITIHQSNLSVLKQVGEEMQLTWAQNAITCGFNAL
EQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
 
maleylacetoacetate isomerase isoform 3
Refseq ID:NP_001504
Protein GI:22202622
UniProt ID:O43708
mRNA ID:NM_001513
Length:161
RefSeq Status:
MKQVPTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCV
GDEVTMADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
 
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