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MGP001360

UniProt Annotations

Entry Information
Gene Nameglutathione S-transferase zeta 1
Protein EntryMAAI_HUMAN
UniProt IDO43708
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O43708-1; Sequence=Displayed; Name=2; IsoId=O43708-2; Sequence=VSP_039862; Name=3; IsoId=O43708-3; Sequence=VSP_047392; Note=Gene prediction based on EST data.;
Catalytic Activity4-maleylacetoacetate = 4-fumarylacetoacetate. {ECO:0000269|PubMed:10739172}.
Catalytic ActivityRX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed:10739172}.
CofactorName=glutathione; Xref=ChEBI:CHEBI:57925; Note=Glutathione is required for the MAAI activity.;
FunctionBifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T- butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. {ECO:0000269|PubMed:10739172}.
InteractionP16333:NCK1; NbExp=2; IntAct=EBI-748043, EBI-389883;
PathwayAmino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6.
SimilarityBelongs to the GST superfamily. Zeta family. {ECO:0000305}.
SimilarityContains 1 GST C-terminal domain. {ECO:0000305}.
SimilarityContains 1 GST N-terminal domain. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitHomodimer. {ECO:0000269|PubMed:11327815}.
Tissue SpecificityMostly expressed in liver followed by kidney, skeletal muscle and brain. Also expressed in melanocytes, synovium, placenta, breast and fetal liver and heart.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gstz1/";
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