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MGP001382

Record overview

MGPD IDMGP001382
Gene ID2987
SpeciesHomo sapiens (Human)
Gene Nameguanylate kinase 1
Gene Symbol GUK1
SynonymsGMK;
Alternate namesguanylate kinase; ATP:GMP phosphotransferase; GMP kinase;
Chromosome1
Map Location1q32-q41
EC Number2.7.4.8
SummaryThe protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
OrthologsView orthologs and multiple alignments for GUK1

Proteins

guanylate kinase isoform a
Refseq ID:NP_001152862
Protein GI:226874831
UniProt ID:Q16774
mRNA ID:NM_001159390
Length:218
RefSeq Status:
MLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGN
LYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYA
ELKEALSEEIKKAQRTGA
 
guanylate kinase isoform b
Refseq ID:NP_001152863
Protein GI:226874833
UniProt ID:Q16774
mRNA ID:NM_001159391
Length:197
RefSeq Status:
MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVL
DVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQRTGA
 
guanylate kinase isoform b
Refseq ID:NP_000849
Protein GI:4504221
UniProt ID:Q16774
mRNA ID:NM_000858
Length:197
RefSeq Status:
Protein sequence is identical to GI:226874833 (mRNA isoform)
 
guanylate kinase isoform b
Refseq ID:NP_001229768
Protein GI:338827696
UniProt ID:Q16774
mRNA ID:NM_001242839
Length:197
RefSeq Status:
Protein sequence is identical to GI:226874833 (mRNA isoform)
 
guanylate kinase isoform c
Refseq ID:NP_001229769
Protein GI:338827698
UniProt ID:Q16774
mRNA ID:NM_001242840
Length:241
RefSeq Status:
MLRRPLAGLAAAALGRAPPDGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGN
LYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESRNQESSKDRRLRLAVCSRHPG
PIQDQGSSIEPPPWQAIRQLCALGQHVEWRRCCPCGWNILG
 
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