MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001382

UniProt Annotations

Entry Information
Gene Nameguanylate kinase 1
Protein EntryKGUA_HUMAN
UniProt IDQ16774
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q16774-1; Sequence=Displayed; Name=2; IsoId=Q16774-2; Sequence=VSP_043778; Name=3; IsoId=Q16774-3; Sequence=VSP_043778, VSP_047372; Note=Gene prediction based on EST data.;
Catalytic ActivityATP + GMP = ADP + GDP.
FunctionEssential for recycling GMP and indirectly, cGMP.
MiscellaneousIn addition to phosphorylating GMP, antiviral prodrugs such as acyclovir, ganciclovir, and carbovir and anticancer prodrugs such as the thiopurines are dependent on GMPK for their activation.
SimilarityBelongs to the guanylate kinase family. {ECO:0000305}.
SimilarityContains 1 guanylate kinase-like domain. {ECO:0000255|PROSITE-ProRule:PRU00100}.
SubunitMonomer. {ECO:0000250}.
  logo