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MGP001389

Record overview

MGPD IDMGP001389
Gene ID3002
SpeciesHomo sapiens (Human)
Gene Namegranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Gene Symbol GZMB
SynonymsHLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1;
Alternate namesgranzyme B; C11; CTLA-1; T-cell serine protease 1-3E; cathepsin G-like 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic serine protease B; fragmentin 2; fragmentin-2; human lymphocyte protein;
Chromosome14
Map Location14q11.2
EC Number3.4.21.79
SummaryCytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for GZMB

Proteins

granzyme B precursor
Refseq ID:NP_004122
Protein GI:221625528
UniProt ID:P10144
mRNA ID:NM_004131
Length:247
RefSeq Status:
MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAY
NPKNFSNDIMLLQLERKAKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIKKTSFK
GDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWIKKTMKRY
 
sig_peptide: 1..20
calculated_mol_wt: 2195
peptide sequence: 
MQPILLLLAFLLLPRADAGE

mat_peptide: 21..247
product: granzyme B
calculated_mol_wt: 25540
peptide sequence: 
IIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYG
RNNGMPPRACTKVSSFVHWIKKTMKRY
 
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