MGP Database

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MGP001389

UniProt Annotations

Entry Information
Gene Namegranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Protein EntryGRAB_HUMAN
UniProt IDP10144
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityPreferential cleavage: -Asp-|-Xaa- >> -Asn-|- Xaa- > -Met-|-Xaa-, -Ser-|-Xaa-. {ECO:0000269|PubMed:8258716}.
Enzyme RegulationInactivated by the serine protease inhibitor diisopropylfluorophosphate. {ECO:0000269|PubMed:8258716}.
FunctionThis enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
InductionBy staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes.
InteractionP14222:PRF1; NbExp=3; IntAct=EBI-2505785, EBI-724466; P10124:SRGN; NbExp=2; IntAct=EBI-2505785, EBI-744915;
SimilarityBelongs to the peptidase S1 family. Granzyme subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
SimilarityContains 1 peptidase S1 domain. {ECO:0000255|PROSITE- ProRule:PRU00274}.
Subcellular LocationCytoplasmic granule {ECO:0000269|PubMed:8258716}. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
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