MGP Database

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MGP001389

Ontology/Pathway Information

Entrez Gene ID3002
Gene Namegranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Gene Symbol GZMB
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0001772 TAS:UniProtKBCimmunological synapse
GO:0043231 IDA:HPACintracellular membrane-bounded organelle
GO:0016020 IDA:UniProtKBCmembrane
GO:0005634 TAS:UniProtKBCnucleus
GO:0030141 IBA:GO_CentralCsecretory granule
GO:0004252 IDA:UniProtKBFserine-type endopeptidase activity
GO:0008236 TAS:ProtIncFserine-type peptidase activity
GO:0006915 TAS:UniProtKBPapoptotic process
GO:0019835 IEA:UniProtKB-KWPcytolysis
GO:0008626 IBA:GO_CentralPgranzyme-mediated apoptotic signaling pathway
GO:0097193 TAS:ReactomePintrinsic apoptotic signaling pathway
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:1900740 TAS:ReactomePpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0006508 IBA:GO_CentralPproteolysis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_701Activation, myristolyation of BID and translocation to mitochondria
REACT_578Apoptosis
REACT_964Intrinsic Pathway for Apoptosis
REACT_163910NOTCH2 intracellular domain regulates transcription
REACT_268456Programmed Cell Death
REACT_299Signaling by NOTCH
REACT_118721Signaling by NOTCH2
REACT_111102Signal Transduction
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