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MGP001445

Record overview

MGPD IDMGP001445
Gene ID3109
SpeciesHomo sapiens (Human)
Gene Namemajor histocompatibility complex, class II, DM beta
Gene Symbol HLA-DMB
SynonymsRING7; D6S221E;
Alternate namesHLA class II histocompatibility antigen, DM beta chain; MHC class II HLA-DMB; MHC class II antigen DMB; MHC class II antigen HLA-DM beta chain; class II histocompatibility antigen, M beta chain; really interesting new gene 7 protein;
Chromosome6
Map Location6p21.3
SummaryHLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HLA-DMB

Proteins

HLA class II histocompatibility antigen, DM beta chain precursor
Refseq ID:NP_002109
Protein GI:301129275
UniProt ID:P28068
mRNA ID:NM_002118
Length:263
RefSeq Status:
MITFLPLLLGLSLGCTGAGGFVAHVESTCLLDDAGTPKDFTYCISFNKDLLTCWDPEENKMAPCEFGVLNSLANVLSQHLNQKDTLMQRLRNGLQNCATH
TQPFWGSLTNRTRPPSVQVAKTTPFNTREPVMLACYVWGFYPAEVTITWRKNGKLVMPHSSAHKTAQPNGDWTYQTLSHLALTPSYGDTYTCVVEHTGAP
EPILRDWTPGLSPMQTLKVSVSAVTLGLGLIIFSLGVISWRRAGHSSYTPLPGSNYSEGWHIS
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1820
peptide sequence: 
MITFLPLLLGLSLGCTGA

mat_peptide: 19..263
product: HLA class II histocompatibility antigen, DM beta chain
calculated_mol_wt: 27129
peptide sequence: 
GGFVAHVESTCLLDDAGTPKDFTYCISFNKDLLTCWDPEENKMAPCEFGVLNSLANVLSQHLNQKDTLMQRLRNGLQNCATHTQPFWGSLTNRTRPPSVQ
VAKTTPFNTREPVMLACYVWGFYPAEVTITWRKNGKLVMPHSSAHKTAQPNGDWTYQTLSHLALTPSYGDTYTCVVEHTGAPEPILRDWTPGLSPMQTLK
VSVSAVTLGLGLIIFSLGVISWRRAGHSSYTPLPGSNYSEGWHIS
 
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