MGP Database

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MGP001445

UniProt Annotations

Entry Information
Gene Namemajor histocompatibility complex, class II, DM beta
Protein EntryDMB_HUMAN
UniProt IDP28068
SpeciesHuman
Comments
Comment typeDescription
DomainThe YXXZ (Tyr-Xaa-Xaa-Zaa, where Zaa is a hydrophobic residue) motif mediates the targeting to the lysosomal compartments.
FunctionPlays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}.
PolymorphismThe following alleles of DMB are known: DMB*01:01, DMB*01:02, DMB*01:03, DMB*01:04 (DMB3.4), DMB*01:05, DMB*01:06, and DMB*01:07. The sequence shown is that of DMB*01:01.
SimilarityBelongs to the MHC class II family. {ECO:0000305}.
SimilarityContains 1 Ig-like C1-type (immunoglobulin-like) domain. {ECO:0000305}.
Subcellular LocationLate endosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Lysosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
SubunitHeterodimer of an alpha chain (DMA) and a beta chain (DMB). {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:9768757}.
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