MGP Database

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MGP001464

Record overview

MGPD IDMGP001464
Gene ID3148
SpeciesHomo sapiens (Human)
Gene Namehigh mobility group box 2
Gene Symbol HMGB2
SynonymsHMG2;
Alternate nameshigh mobility group protein B2; HMG-2; high mobility group protein 2; high-mobility group (nonhistone chromosomal) protein 2; high-mobility group box 2;
Chromosome4
Map Location4q31
SummaryThis gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HMGB2

Proteins

high mobility group protein B2
Refseq ID:NP_002120
Protein GI:11321591
UniProt ID:P26583
mRNA ID:NM_002129
Length:209
RefSeq Status:
MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPS
AFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDED
EEEEDEDEE
 
high mobility group protein B2
Refseq ID:NP_001124161
Protein GI:194688135
UniProt ID:P26583
mRNA ID:NM_001130689
Length:209
RefSeq Status:
Protein sequence is identical to GI:11321591 (mRNA isoform)
 
high mobility group protein B2
Refseq ID:NP_001124160
Protein GI:194688133
UniProt ID:P26583
mRNA ID:NM_001130688
Length:209
RefSeq Status:
Protein sequence is identical to GI:11321591 (mRNA isoform)
 
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