MGP Database

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MGP001464

UniProt Annotations

Entry Information
Gene Namehigh mobility group box 2
Protein EntryHMGB2_HUMAN
UniProt IDP26583
SpeciesHuman
Comments
Comment typeDescription
FunctionDNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). {ECO:0000250}.
SimilarityBelongs to the HMGB family. {ECO:0000305}.
SimilarityContains 2 HMG box DNA-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00267}.
Subcellular LocationNucleus. Chromosome.
SubunitComponent of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET. {ECO:0000269|PubMed:11909973}.
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