MGP Database

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MGP001464

Ontology/Pathway Information

Entrez Gene ID3148
Gene Namehigh mobility group box 2
Gene Symbol HMGB2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0000793 IDA:UniProtKBCcondensed chromosome
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005615 IDA:UniProtKBCextracellular space
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0043234 IDA:UniProtKBCprotein complex
GO:0042056 IDA:UniProtKBFchemoattractant activity
GO:0003682 IBA:GO_CentralFchromatin binding
GO:0003684 IDA:UniProtKBFdamaged DNA binding
GO:0003677 IMP:UniProtKBFDNA binding
GO:0008301 IDA:UniProtKBFDNA binding, bending
GO:0003690 ISS:UniProtKBFdouble-stranded DNA binding
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0050786 IGI:UniProtKBFRAGE receptor binding
GO:0003700 IDA:UniProtKBFsequence-specific DNA binding transcription factor activity
GO:0003697 ISS:UniProtKBFsingle-stranded DNA binding
GO:0044212 IDA:UniProtKBFtranscription regulatory region DNA binding
GO:0006309 TAS:ReactomePapoptotic DNA fragmentation
GO:0006915 TAS:ReactomePapoptotic process
GO:0006288 IDA:UniProtKBPbase-excision repair, DNA ligation
GO:0060326 IDA:UniProtKBPcell chemotaxis
GO:0006921 TAS:ReactomePcellular component disassembly involved in execution phase of apoptosis
GO:0071222 IEP:UniProtKBPcellular response to lipopolysaccharide
GO:0006325 NAS:UniProtKBPchromatin organization
GO:0006338 IBA:GO_CentralPchromatin remodeling
GO:0051103 ISS:UniProtKBPDNA ligation involved in DNA repair
GO:0006265 ISS:UniProtKBPDNA topological change
GO:0008584 IEA:EnsemblPmale gonad development
GO:1902042 IEA:EnsemblPnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045892 IDA:BHF-UCLPnegative regulation of transcription, DNA-templated
GO:0006334 NAS:UniProtKBPnucleosome assembly
GO:0050918 IDA:GOCPpositive chemotaxis
GO:0043388 IDA:UniProtKBPpositive regulation of DNA binding
GO:0001938 IDA:UniProtKBPpositive regulation of endothelial cell proliferation
GO:0045648 IMP:UniProtKBPpositive regulation of erythrocyte differentiation
GO:0045654 IMP:UniProtKBPpositive regulation of megakaryocyte differentiation
GO:0032075 IDA:UniProtKBPpositive regulation of nuclease activity
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0006357 IDA:UniProtKBPregulation of transcription from RNA polymerase II promoter
GO:0048545 IEA:EnsemblPresponse to steroid hormone
GO:0007289 IEA:EnsemblPspermatid nucleus differentiation
GO:0033151 ISS:UniProtKBPV(D)J recombination
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13462Activation of DNA fragmentation factor
REACT_578Apoptosis
REACT_1213Apoptosis induced DNA fragmentation
REACT_995Apoptotic execution phase
REACT_268456Programmed Cell Death
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