MGP Database

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MGP001493

Record overview

MGPD IDMGP001493
Gene ID3248
SpeciesHomo sapiens (Human)
Gene Namehydroxyprostaglandin dehydrogenase 15-(NAD)
Gene Symbol HPGD
SynonymsPGDH; PGDH1; PHOAR1; 15-PGDH; SDR36C1;
Alternate names15-hydroxyprostaglandin dehydrogenase [NAD(+)]; NAD+-dependent 15-hydroxyprostaglandin dehydrogenase; prostaglandin dehydrogenase 1; short chain dehydrogenase/reductase family 36C, member 1;
Chromosome4
Map Location4q34-q35
EC Number1.1.1.141
SummaryThis gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
OrthologsView orthologs and multiple alignments for HPGD

Proteins

15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1
Refseq ID:NP_000851
Protein GI:31542939
UniProt ID:P15428
mRNA ID:NM_000860
Length:266
RefSeq Status:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW
EKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENM
GQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
 
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 2
Refseq ID:NP_001139288
Protein GI:224922801
UniProt ID:P15428
mRNA ID:NM_001145816
Length:178
RefSeq Status:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW
EKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAAPTIDCQWIDNTH
 
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3
Refseq ID:NP_001243230
Protein GI:372626410
UniProt ID:P15428
mRNA ID:NM_001256301
Length:145
RefSeq Status:
MSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILD
PPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
 
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3
Refseq ID:NP_001243236
Protein GI:372626423
UniProt ID:P15428
mRNA ID:NM_001256307
Length:145
RefSeq Status:
Protein sequence is identical to GI:372626410 (mRNA isoform)
 
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 4
Refseq ID:NP_001243234
Protein GI:372626421
UniProt ID:P15428
mRNA ID:NM_001256305
Length:143
RefSeq Status:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW
EKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAAHH
 
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 5
Refseq ID:NP_001243235
Protein GI:372626419
UniProt ID:P15428
mRNA ID:NM_001256306
Length:198
RefSeq Status:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRGLMPVAQQPVYCASKHGIVGFTRSAALA
ANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
 
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