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MGP001493

UniProt Annotations

Entry Information
Gene Namehydroxyprostaglandin dehydrogenase 15-(NAD)
Protein EntryPGDH_HUMAN
UniProt IDP15428
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=P15428-1; Sequence=Displayed; Name=2; IsoId=P15428-2; Sequence=VSP_043032; Name=3; IsoId=P15428-3; Sequence=VSP_045106; Name=4; IsoId=P15428-4; Sequence=VSP_045107, VSP_045108; Name=5; IsoId=P15428-5; Sequence=VSP_045579; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=3.4 uM for prostaglandin E2 {ECO:0000269|PubMed:16828555}; KM=38 uM for NAD {ECO:0000269|PubMed:16828555};
Catalytic Activity(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost- 5,13-dienoate + NAD(+) = (5Z,13E)-11-alpha-hydroxy-9,15- dioxoprost-5,13-dienoate + NADH.
DiseaseCranioosteoarthropathy (COA) [MIM:259100]: A form of osteoarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature. {ECO:0000269|PubMed:18500342}. Note=The disease is caused by mutations affecting the gene represented in this entry.
DiseaseHypertrophic osteoarthropathy, primary, autosomal recessive, 1 (PHOAR1) [MIM:259100]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. {ECO:0000269|PubMed:18500342}. Note=The disease is caused by mutations affecting the gene represented in this entry.
DiseaseIsolated congenital nail clubbing (ICNC) [MIM:119900]: A rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved. {ECO:0000269|PubMed:18805827}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionProstaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells. {ECO:0000269|PubMed:10837478, ECO:0000269|PubMed:15574495, ECO:0000269|PubMed:16828555}.
InductionDown-regulated by cortisol, dexamethasone and betamethasone. Down-regulated in colon cancer. Up-regulated by TGFB1. {ECO:0000269|PubMed:12788907, ECO:0000269|PubMed:15574495}.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000269|PubMed:21072165}.
Tissue SpecificityDetected in colon epithelium (at protein level). {ECO:0000269|PubMed:15574495}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/hpgd/";
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