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MGP Database

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MGP001537

Ontology/Pathway Information

Entrez Gene ID	3362
Gene Name	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
Gene Symbol	HTR6
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005929	IEA:Ensembl	C	cilium
GO:0030425	IEA:Ensembl	C	dendrite
GO:0005887	TAS:ProtInc	C	integral component of plasma membrane
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0004969	TAS:ProtInc	F	histamine receptor activity
GO:0004993	IEA:InterPro	F	serotonin receptor activity
GO:0021795	ISS:UniProtKB	P	cerebral cortex cell migration
GO:0007187	TAS:ProtInc	P	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007612	IEA:Ensembl	P	learning
GO:0060291	IEA:Ensembl	P	long-term synaptic potentiation
GO:0014058	IEA:Ensembl	P	negative regulation of acetylcholine secretion, neurotransmission
GO:0014053	IEA:Ensembl	P	negative regulation of gamma-aminobutyric acid secretion
GO:0014050	IEA:Ensembl	P	negative regulation of glutamate secretion
GO:0033603	IEA:Ensembl	P	positive regulation of dopamine secretion
GO:0014054	IEA:Ensembl	P	positive regulation of gamma-aminobutyric acid secretion
GO:0032008	IDA:UniProtKB	P	positive regulation of TOR signaling
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0007268	TAS:ProtInc	P	synaptic transmission

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_16983	Amine ligand-binding receptors
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_19327	G alpha (s) signalling events
REACT_19184	GPCR downstream signaling
REACT_21340	GPCR ligand binding
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_17064	Serotonin receptors
REACT_14797	Signaling by GPCR
REACT_111102	Signal Transduction

SMP Pathway Links

SMP ID	Description
SMP00312	Excitatory Neural Signalling Through 5-HTR 6 and Serotonin