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MGP001537

UniProt Annotations

Entry Information
Gene Name5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
Protein Entry5HT6R_HUMAN
UniProt IDP50406
SpeciesHuman
Comments
Comment typeDescription
FunctionThis is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611). {ECO:0000250|UniProtKB:P31388, ECO:0000250|UniProtKB:Q9R1C8, ECO:0000269|PubMed:23027611}.
InteractionP06241:FYN; NbExp=7; IntAct=EBI-1182222, EBI-515315;
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitInteracts with MTOR, RPTOR and NF1 (PubMed:23027611). Interacts with CDK5 (By similarity). {ECO:0000250|UniProtKB:Q9R1C8, ECO:0000269|PubMed:23027611}.
Tissue SpecificityExpressed in several human brain regions, most prominently in the caudate nucleus.
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