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MGP001565

UniProt Annotations

Entry Information
Gene Nameinterferon-induced protein with tetratricopeptide repeats 1
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P09914-1; Sequence=Displayed; Name=2; IsoId=P09914-2; Sequence=VSP_054831; Note=No experimental confirmation available.;
DomainRNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffolds unique additional helices that form an RNA binding cleft. {ECO:0000250}.
FunctionInterferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single- stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:19416887, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:23334420}.
InductionBy type I interferons, dsRNAs and viruses. {ECO:0000269|PubMed:3753936}.
InteractionP06789:E1 (xeno); NbExp=8; IntAct=EBI-745117, EBI-7015660; P09913:IFIT2; NbExp=5; IntAct=EBI-745117, EBI-3507167; O14879:IFIT3; NbExp=5; IntAct=EBI-745117, EBI-745127;
PtmISGylated. {ECO:0000269|PubMed:16009940}.
PtmPhosphorylated. {ECO:0000269|PubMed:19416887}.
SimilarityBelongs to the IFIT family. {ECO:0000305}.
SimilarityContains 10 TPR repeats. {ECO:0000255|PROSITE- ProRule:PRU00339}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:21642987}.
SubunitComponent of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts (via TPR repeats 4-7) with EEF1A1 (By similarity). Interacts with EIF3C (By similarity). Interacts with IFIT2 and IFIT3. Interacts (via TPR repeats 1-4) with RPL15. Interacts with TMEM173/MITA and disrupts its interaction with MAVS or TBK1. Interacts with EIF3E. Interacts (via TPR repeat 2) with E1 proteins of HPV types 11, 18 and 3 and this interaction blocks E1 helicase activity and viral replication. {ECO:0000250, ECO:0000269|PubMed:16023166, ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:19416887, ECO:0000269|PubMed:21190939, ECO:0000269|PubMed:21612406, ECO:0000269|PubMed:21642987}.
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