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MGP001600

Record overview

MGPD IDMGP001600
Gene ID3552
SpeciesHomo sapiens (Human)
Gene Nameinterleukin 1, alpha
Gene Symbol IL1A
SynonymsIL1; IL-1A; IL1F1; IL1-ALPHA;
Alternate namesinterleukin-1 alpha; IL-1 alpha; hematopoietin-1; preinterleukin 1 alpha; pro-interleukin-1-alpha;
Chromosome2
Map Location2q14
SummaryThe protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for IL1A

Proteins

interleukin-1 alpha proprotein
Refseq ID:NP_000566
Protein GI:27894330
UniProt ID:P01583
mRNA ID:NM_000575
Length:271
RefSeq Status:
MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYHVSYGPLHEGCMDQSVSLSISETSKTSKLTFKESMVVVATNGKVLKKRRLSLSQSITDDDLEAI
ANDSEEEIIKPRSAPFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQ
PVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQA
 
mat_peptide: 113..271
product: interleukin-1 alpha
calculated_mol_wt: 18048
peptide sequence: 
SAPFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPK
TITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQA
 
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