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MGP001600

UniProt Annotations

Entry Information
Gene Nameinterleukin 1, alpha
Protein EntryIL1A_HUMAN
UniProt IDP01583
SpeciesHuman
Comments
Comment typeDescription
DomainThe similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
FunctionProduced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
InteractionP29466:CASP1; NbExp=3; IntAct=EBI-1749782, EBI-516667;
SimilarityBelongs to the IL-1 family. {ECO:0000305}.
Subcellular LocationSecreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
SubunitMonomer.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il1a/";
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1A";
Web ResourceName=Wikipedia; Note=Interleukin-1 entry; URL="http://en.wikipedia.org/wiki/Interleukin_1";
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