MGP Database

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MGP001600

Ontology/Pathway Information

Entrez Gene ID3552
Gene Nameinterleukin 1, alpha
Gene Symbol IL1A
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 IDA:UniProtKBCcytosol
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0005507 IDA:UniProtKBFcopper ion binding
GO:0005125 IMP:BHF-UCLFcytokine activity
GO:0006915 TAS:ProtIncPapoptotic process
GO:0008283 TAS:ProtIncPcell proliferation
GO:0034605 IDA:UniProtKBPcellular response to heat
GO:0019221 IMP:BHF-UCLPcytokine-mediated signaling pathway
GO:0035234 IEA:EnsemblPectopic germ cell programmed cell death
GO:0097192 IEA:EnsemblPextrinsic apoptotic signaling pathway in absence of ligand
GO:0001660 IEA:UniProtKB-KWPfever generation
GO:0006955 IEA:InterProPimmune response
GO:0006954 TAS:ProtIncPinflammatory response
GO:0008285 IDA:BHF-UCLPnegative regulation of cell proliferation
GO:2001240 TAS:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0045766 ISS:BHF-UCLPpositive regulation of angiogenesis
GO:0050715 IDA:BHF-UCLPpositive regulation of cytokine secretion
GO:0070374 IBA:GO_CentralPpositive regulation of ERK1 and ERK2 cascade
GO:0043123 IBA:GO_CentralPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045086 IMP:BHF-UCLPpositive regulation of interleukin-2 biosynthetic process
GO:0046330 IBA:GO_CentralPpositive regulation of JNK cascade
GO:0045840 IMP:BHF-UCLPpositive regulation of mitosis
GO:0045944 IEA:EnsemblPpositive regulation of transcription from RNA polymerase II promoter
GO:0010575 ISS:BHF-UCLPpositive regulation vascular endothelial growth factor production
GO:0046688 IDA:UniProtKBPresponse to copper ion
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_75790Cytokine Signaling in Immune system
REACT_6900Immune System
REACT_23950Interleukin-1 processing
REACT_22442Interleukin-1 signaling
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_22232Signaling by Interleukins
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