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MGP001610

Record overview

MGPD IDMGP001610
Gene ID3565
SpeciesHomo sapiens (Human)
Gene Nameinterleukin 4
Gene Symbol IL4
SynonymsBSF1; IL-4; BCGF1; BSF-1; BCGF-1;
Alternate namesinterleukin-4; B cell growth factor 1; B_cell stimulatory factor 1; binetrakin; interleukin 4 variant 2; lymphocyte stimulatory factor 1; pitrakinra;
Chromosome5
Map Location5q31.1
SummaryThe protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for IL4

Proteins

interleukin-4 isoform 1 precursor
Refseq ID:NP_000580
Protein GI:4504669
UniProt ID:P05112
mRNA ID:NM_000589
Length:153
RefSeq Status:
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRH
KQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2547
peptide sequence: 
MGLTSQLLPPLFFLLACAGNFVHG

mat_peptide: 25..137
product: interleukin-4 isoform 2
calculated_mol_wt: 13268
peptide sequence: 
HKCDITLQEIIKTLNSLTEQKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERL
KTIMREKYSKCSS

sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2547
peptide sequence: 
MGLTSQLLPPLFFLLACAGNFVHG

mat_peptide: 25..153
product: Interleukin-4
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P05112.1)
calculated_mol_wt: 14963
peptide sequence: 
HKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCP
VKEANQSTLENFLERLKTIMREKYSKCSS
 
interleukin-4 isoform 2 precursor
Refseq ID:NP_758858
Protein GI:27477092
UniProt ID:P05112
mRNA ID:NM_172348
Length:137
RefSeq Status:
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWG
LAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2547
peptide sequence: 
MGLTSQLLPPLFFLLACAGNFVHG

mat_peptide: 25..137
product: interleukin-4 isoform 2
calculated_mol_wt: 13268
peptide sequence: 
HKCDITLQEIIKTLNSLTEQKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERL
KTIMREKYSKCSS
 
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