MGP Database

MGP001610

Ontology/Pathway Information

Entrez Gene ID	3565
Gene Name	interleukin 4
Gene Symbol	IL4
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0009897	IEA:Ensembl	C	external side of plasma membrane
GO:0005615	TAS:UniProtKB	C	extracellular space
GO:0005125	IBA:GO_Central	F	cytokine activity
GO:0008083	NAS:UniProtKB	F	growth factor activity
GO:0005136	TAS:UniProtKB	F	interleukin-4 receptor binding
GO:0042113	IBA:GO_Central	P	B cell activation
GO:0031296	IEA:Ensembl	P	B cell costimulation
GO:0030183	TAS:UniProtKB	P	B cell differentiation
GO:0006968	TAS:ProtInc	P	cellular defense response
GO:0071288	IEA:Ensembl	P	cellular response to mercury ion
GO:0006935	TAS:ProtInc	P	chemotaxis
GO:0008203	ISS:UniProtKB	P	cholesterol metabolic process
GO:0045189	TAS:UniProtKB	P	connective tissue growth factor biosynthetic process
GO:0042832	IEA:Ensembl	P	defense response to protozoan
GO:0097028	IDA:DFLAT	P	dendritic cell differentiation
GO:0097192	IEA:Ensembl	P	extrinsic apoptotic signaling pathway in absence of ligand
GO:0007565	IEA:Ensembl	P	female pregnancy
GO:0006955	TAS:ProtInc	P	immune response
GO:0002227	IEA:Ensembl	P	innate immune response in mucosa
GO:0001774	IEA:Ensembl	P	microglial cell activation
GO:0002674	IEA:Ensembl	P	negative regulation of acute inflammatory response
GO:0043066	ISS:UniProtKB	P	negative regulation of apoptotic process
GO:0002677	IEA:Ensembl	P	negative regulation of chronic inflammatory response
GO:2001237	IEA:Ensembl	P	negative regulation of extrinsic apoptotic signaling pathway
GO:0043031	IEA:Ensembl	P	negative regulation of macrophage activation
GO:0045019	IEA:Ensembl	P	negative regulation of nitric oxide biosynthetic process
GO:0045671	ISS:UniProtKB	P	negative regulation of osteoclast differentiation
GO:2000320	IEA:Ensembl	P	negative regulation of T-helper 17 cell differentiation
GO:0045892	IDA:UniProtKB	P	negative regulation of transcription, DNA-templated
GO:0042104	IEA:Ensembl	P	positive regulation of activated T cell proliferation
GO:0030890	ISS:UniProtKB	P	positive regulation of B cell proliferation
GO:0045080	IEA:Ensembl	P	positive regulation of chemokine biosynthetic process
GO:0002230	IEA:Ensembl	P	positive regulation of defense response to virus by host
GO:2000424	IEA:Ensembl	P	positive regulation of eosinophil chemotaxis
GO:0032733	IEA:Ensembl	P	positive regulation of interleukin-10 production
GO:0032736	IDA:UniProtKB	P	positive regulation of interleukin-13 production
GO:0048295	ISS:UniProtKB	P	positive regulation of isotype switching to IgE isotypes
GO:0048304	ISS:UniProtKB	P	positive regulation of isotype switching to IgG isotypes
GO:0045348	ISS:UniProtKB	P	positive regulation of MHC class II biosynthetic process
GO:0071677	IEA:Ensembl	P	positive regulation of mononuclear cell migration
GO:0051091	IBA:GO_Central	P	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045582	IDA:UniProtKB	P	positive regulation of T cell differentiation
GO:0042102	ISS:UniProtKB	P	positive regulation of T cell proliferation
GO:0045893	IDA:UniProtKB	P	positive regulation of transcription, DNA-templated
GO:0045944	ISS:UniProtKB	P	positive regulation of transcription from RNA polymerase II promoter
GO:0042523	IEA:Ensembl	P	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0050776	ISS:UniProtKB	P	regulation of immune response
GO:0045191	TAS:UniProtKB	P	regulation of isotype switching
GO:0042325	ISS:UniProtKB	P	regulation of phosphorylation
GO:0010155	IEA:Ensembl	P	regulation of proton transport
GO:0034097	IEA:Ensembl	P	response to cytokine
GO:0042493	IEA:Ensembl	P	response to drug
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0007584	IEA:Ensembl	P	response to nutrient
GO:0014070	IEA:Ensembl	P	response to organic cyclic compound
GO:0060041	IEA:Ensembl	P	retina development in camera-type eye
GO:0002296	IEA:Ensembl	P	T-helper 1 cell lineage commitment
GO:0035745	IDA:UniProtKB	P	T-helper 2 cell cytokine production
GO:0045064	IEA:Ensembl	P	T-helper 2 cell differentiation
GO:0042092	TAS:UniProtKB	P	type 2 immune response

SMP Pathway Links

SMP ID	Description
SMP00358	Fc Epsilon Receptor I Signaling in Mast Cells