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MGP001610

UniProt Annotations

Entry Information
Gene Nameinterleukin 4
Protein EntryIL4_HUMAN
UniProt IDP05112
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=P05112-1; Sequence=Displayed; Name=2; Synonyms=Short, IL-4delta2; IsoId=P05112-2; Sequence=VSP_002672;
DiseaseIschemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269|PubMed:14681304}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
FunctionParticipates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
InteractionP78552:IL13RA1; NbExp=3; IntAct=EBI-367025, EBI-1391535; P24394:IL4R; NbExp=7; IntAct=EBI-367025, EBI-367009;
SimilarityBelongs to the IL-4/IL-13 family. {ECO:0000305}.
Subcellular LocationSecreted.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il4/";
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