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MGP001613

Record overview

MGPD IDMGP001613
Gene ID3569
SpeciesHomo sapiens (Human)
Gene Nameinterleukin 6
Gene Symbol IL6
SynonymsHGF; HSF; BSF2; IL-6; IFNB2;
Alternate namesinterleukin-6; B-cell differentiation factor; B-cell stimulatory factor 2; BSF-2; CDF; CTL differentiation factor; IFN-beta-2; hybridoma growth factor; interferon beta-2; interferon, beta 2; interleukin BSF-2;
Chromosome7
Map Location7p21
SummaryThis gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]
OrthologsView orthologs and multiple alignments for IL6

Proteins

interleukin-6 precursor
Refseq ID:NP_000591
Protein GI:10834984
UniProt ID:P05231
mRNA ID:NM_000600
Length:212
RefSeq Status:
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDG
CFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKE
FLQSSLRALRQM
 
sig_peptide: 1..29
calculated_mol_wt: 2923
peptide sequence: 
MNSFSTSAFGPVAFSLGLLLVLPAAFPAP

mat_peptide: 30..212
product: interleukin-6
calculated_mol_wt: 20813
peptide sequence: 
VPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYL
QNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
 
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