MGP Database

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MGP001613

Ontology/Pathway Information

Entrez Gene ID3569
Gene Nameinterleukin 6
Gene Symbol IL6
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IEA:EnsemblCcytoplasm
GO:0009897 IEA:EnsemblCexternal side of plasma membrane
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0005896 IDA:BHF-UCLCinterleukin-6 receptor complex
GO:0005125 IDA:BHF-UCLFcytokine activity
GO:0008083 IDA:BHF-UCLFgrowth factor activity
GO:0005138 NAS:UniProtKBFinterleukin-6 receptor binding
GO:0006953 TAS:BHF-UCLPacute-phase response
GO:0007568 IEA:EnsemblPaging
GO:0046849 IEA:EnsemblPbone remodeling
GO:0060445 IEA:EnsemblPbranching involved in salivary gland morphogenesis
GO:0016049 IEA:EnsemblPcell growth
GO:0045454 IEA:EnsemblPcell redox homeostasis
GO:0071549 IEA:EnsemblPcellular response to dexamethasone stimulus
GO:0070301 IDA:BHF-UCLPcellular response to hydrogen peroxide
GO:0071347 IEA:EnsemblPcellular response to interleukin-1
GO:0071222 IMP:MGIPcellular response to lipopolysaccharide
GO:0071356 IEA:EnsemblPcellular response to tumor necrosis factor
GO:0019221 IDA:BHF-UCLPcytokine-mediated signaling pathway
GO:0050829 IEP:BHF-UCLPdefense response to Gram-negative bacterium
GO:0050830 IEP:BHF-UCLPdefense response to Gram-positive bacterium
GO:0042832 IEA:EnsemblPdefense response to protozoan
GO:0051607 IDA:BHF-UCLPdefense response to virus
GO:0031018 ISS:BHF-UCLPendocrine pancreas development
GO:0060664 IEA:EnsemblPepithelial cell proliferation involved in salivary gland morphogenesis
GO:0070091 ISS:BHF-UCLPglucagon secretion
GO:0002384 IDA:BHF-UCLPhepatic immune response
GO:0006959 IC:BHF-UCLPhumoral immune response
GO:0006954 IDA:BHF-UCLPinflammatory response
GO:0070102 IDA:BHF-UCLPinterleukin-6-mediated signaling pathway
GO:0002548 IC:BHF-UCLPmonocyte chemotaxis
GO:0046716 IEA:EnsemblPmuscle cell cellular homeostasis
GO:0043066 IDA:UniProtKBPnegative regulation of apoptotic process
GO:0008285 TAS:ProtIncPnegative regulation of cell proliferation
GO:0045079 ISS:UniProtKBPnegative regulation of chemokine biosynthetic process
GO:0032966 IDA:BHF-UCLPnegative regulation of collagen biosynthetic process
GO:0043154 IEA:EnsemblPnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050710 IEA:EnsemblPnegative regulation of cytokine secretion
GO:0045599 NAS:BHF-UCLPnegative regulation of fat cell differentiation
GO:0045721 IEA:EnsemblPnegative regulation of gluconeogenesis
GO:0046888 IEA:EnsemblPnegative regulation of hormone secretion
GO:0010888 NAS:BHF-UCLPnegative regulation of lipid storage
GO:0048635 IEA:EnsemblPnegative regulation of muscle organ development
GO:1901215 IEA:EnsemblPnegative regulation of neuron death
GO:0006469 IEA:EnsemblPnegative regulation of protein kinase activity
GO:0031175 IMP:BHF-UCLPneuron projection development
GO:0001781 IDA:UniProtKBPneutrophil apoptotic process
GO:0002446 IC:BHF-UCLPneutrophil mediated immunity
GO:0030168 TAS:BHF-UCLPplatelet activation
GO:0002675 IDA:BHF-UCLPpositive regulation of acute inflammatory response
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:0050871 IDA:BHF-UCLPpositive regulation of B cell activation
GO:0008284 IDA:BHF-UCLPpositive regulation of cell proliferation
GO:0032722 IDA:BHF-UCLPpositive regulation of chemokine production
GO:0045740 IEA:EnsemblPpositive regulation of DNA replication
GO:0050679 IEA:EnsemblPpositive regulation of epithelial cell proliferation
GO:0070374 IEA:EnsemblPpositive regulation of ERK1 and ERK2 cascade
GO:0051024 IDA:BHF-UCLPpositive regulation of immunoglobulin secretion
GO:0032755 IDA:BHF-UCLPpositive regulation of interleukin-6 production
GO:0046427 IDA:BHF-UCLPpositive regulation of JAK-STAT cascade
GO:0002690 IC:BHF-UCLPpositive regulation of leukocyte chemotaxis
GO:0043410 IDA:BHF-UCLPpositive regulation of MAPK cascade
GO:0045666 IEA:EnsemblPpositive regulation of neuron differentiation
GO:0045429 IEA:EnsemblPpositive regulation of nitric oxide biosynthetic process
GO:0045669 TAS:BHF-UCLPpositive regulation of osteoblast differentiation
GO:0033138 IDA:MGIPpositive regulation of peptidyl-serine phosphorylation
GO:0050731 IDA:MGIPpositive regulation of peptidyl-tyrosine phosphorylation
GO:0033160 IEA:EnsemblPpositive regulation of protein import into nucleus, translocation
GO:0051897 IEA:EnsemblPpositive regulation of protein kinase B signaling
GO:0051091 IDA:BHF-UCLPpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0048661 IDA:BHF-UCLPpositive regulation of smooth muscle cell proliferation
GO:2000366 IC:BHF-UCLPpositive regulation of STAT protein import into nucleus
GO:0042102 IDA:BHF-UCLPpositive regulation of T cell proliferation
GO:0045630 IEA:EnsemblPpositive regulation of T-helper 2 cell differentiation
GO:0045893 IDA:BHF-UCLPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0045727 IDA:UniProtKBPpositive regulation of translation
GO:0051971 IEA:EnsemblPpositive regulation of transmission of nerve impulse
GO:2000676 TAS:BHF-UCLPpositive regulation of type B pancreatic cell apoptotic process
GO:0042517 IDA:BHF-UCLPpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045765 IC:BHF-UCLPregulation of angiogenesis
GO:0008360 IEA:EnsemblPregulation of cell shape
GO:0045188 IEA:EnsemblPregulation of circadian sleep/wake cycle, non-REM sleep
GO:0010574 IDA:BHF-UCLPregulation of vascular endothelial growth factor production
GO:0043200 IEA:EnsemblPresponse to amino acid
GO:0046677 IEA:EnsemblPresponse to antibiotic
GO:0010996 IEA:EnsemblPresponse to auditory stimulus
GO:0031000 IEA:EnsemblPresponse to caffeine
GO:0051592 IEA:EnsemblPresponse to calcium ion
GO:0009409 IEA:EnsemblPresponse to cold
GO:0042493 IEA:EnsemblPresponse to drug
GO:0051602 IEA:EnsemblPresponse to electrical stimulus
GO:0051384 IDA:BHF-UCLPresponse to glucocorticoid
GO:0009408 IEA:EnsemblPresponse to heat
GO:0032868 IEA:EnsemblPresponse to insulin
GO:0031667 IEA:EnsemblPresponse to nutrient levels
GO:0032494 IEP:BHF-UCLPresponse to peptidoglycan
GO:0072540 ISS:UniProtKBPT-helper 17 cell lineage commitment
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_12002ARMS-mediated activation
REACT_18266Axon guidance
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_1391ERK1 activation
REACT_1183ERK2 activation
REACT_1482ERK activation
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_12076Frs2-mediated activation
REACT_21247FRS2-mediated cascade
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_12606GRB2 events in EGFR signaling
REACT_115854GRB2 events in ERBB2 signaling
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_27283Interleukin-2 signaling
REACT_27307Interleukin-6 signaling
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_21308MAP kinase activation in TLR cascade
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_18334NCAM signaling for neurite out-growth
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12005Prolonged ERK activation events
REACT_634RAF/MAP kinase cascade
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_12579SHC1 events in EGFR signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_116005SHC1 events in ERBB4 signaling
REACT_661SHC-mediated signalling
REACT_999SHC-related events
REACT_150139SHC-related events triggered by IGF1R
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_22232Signaling by Interleukins
REACT_169118Signaling by Leptin
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12077Signalling to p38 via RIT and RIN
REACT_12033Signalling to RAS
REACT_111102Signal Transduction
REACT_524SOS-mediated signalling
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
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