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MGP001613

UniProt Annotations

Entry Information
Gene Nameinterleukin 6
Protein EntryIL6_HUMAN
UniProt IDP05231
SpeciesHuman
Comments
Comment typeDescription
DiseaseNote=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
DiseaseRheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic- onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
FunctionCytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
InteractionP08887:IL6R; NbExp=5; IntAct=EBI-720533, EBI-299383; Q05516:ZBTB16; NbExp=2; IntAct=EBI-720533, EBI-711925;
PolymorphismGenetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.
PtmN- and O-glycosylated. {ECO:0000269|PubMed:1883960}.
SimilarityBelongs to the IL-6 superfamily. {ECO:0000305}.
Subcellular LocationSecreted.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/IL6ID519ch7p15.html";
Web ResourceName=R&D Systems' cytokine mini-reviews: IL-6; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1648";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il6/";
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL6";
Web ResourceName=Wikipedia; Note=Interleukin-6 entry; URL="http://en.wikipedia.org/wiki/Interleukin_6";
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