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MGP001618

Record overview

MGPD IDMGP001618
Gene ID3576
SpeciesHomo sapiens (Human)
Gene Namechemokine (C-X-C motif) ligand 8
Gene Symbol CXCL8
SynonymsIL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1;
Alternate namesinterleukin-8; T-cell chemotactic factor; alveolar macrophage chemotactic factor I; beta endothelial cell-derived neutrophil activating peptide; beta-thromboglobulin-like protein; emoctakin; granulocyte chemotactic protein 1; interleukin 8; lung giant cell carcinoma-derived chemotactic protein; lymphocyte derived neutrophil activating peptide; monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; neutrophil-activating peptide 1; small inducible cytokine subfamily B, member 8; tumor necrosis factor-induced gene 1;
Chromosome4
Map Location4q13-q21
SummaryThe protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CXCL8

Proteins

interleukin-8 precursor
Refseq ID:NP_000575
Protein GI:10834978
UniProt ID:P10145
mRNA ID:NM_000584
Length:99
RefSeq Status:
MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS
 
sig_peptide: 1..20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P10145.1)
calculated_mol_wt: 2008
peptide sequence: 
MTSKLAVALLAAFLISAALC

mat_peptide: 21..99
product: MDNCF-a
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P10145.1)
calculated_mol_wt: 9109
peptide sequence: 
EGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS

mat_peptide: 23..99
product: Interleukin-8
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P10145.1)
calculated_mol_wt: 8922
peptide sequence: 
AVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS

mat_peptide: 27..99
product: IL-8(5-77)
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P10145.1)
calculated_mol_wt: 8542
peptide sequence: 
RSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS

mat_peptide: 28..99
product: IL-8(6-77)
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P10145.1)
calculated_mol_wt: 8386
peptide sequence: 
SAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS

mat_peptide: 29..99
product: IL-8(7-77)
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P10145.1)
calculated_mol_wt: 8299
peptide sequence: 
AKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS

mat_peptide: 30..99
product: IL-8(8-77)
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P10145.1)
calculated_mol_wt: 8228
peptide sequence: 
KELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS

mat_peptide: 31..99
product: IL-8(9-77)
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P10145.1)
calculated_mol_wt: 8099
peptide sequence: 
ELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS
 
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