MGP Database

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MGP001618

Ontology/Pathway Information

Entrez Gene ID3576
Gene Namechemokine (C-X-C motif) ligand 8
Gene Symbol CXCL8
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 TAS:ProtIncCextracellular space
GO:0008009 TAS:UniProtKBFchemokine activity
GO:0005153 IPI:UniProtKBFinterleukin-8 receptor binding
GO:0006987 TAS:ReactomePactivation of signaling protein activity involved in unfolded protein response
GO:0001525 TAS:UniProtKBPangiogenesis
GO:0019722 TAS:UniProtKBPcalcium-mediated signaling
GO:0007050 IDA:UniProtKBPcell cycle arrest
GO:0006928 TAS:ProtIncPcellular component movement
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0044344 IEP:UniProtKBPcellular response to fibroblast growth factor stimulus
GO:0071347 IEP:UniProtKBPcellular response to interleukin-1
GO:0071222 IDA:BHF-UCLPcellular response to lipopolysaccharide
GO:0071356 IEP:UniProtKBPcellular response to tumor necrosis factor
GO:0070098 IBA:GO_CentralPchemokine-mediated signaling pathway
GO:0006935 TAS:UniProtKBPchemotaxis
GO:0048566 IEP:DFLATPembryonic digestive tract development
GO:0030968 TAS:ReactomePendoplasmic reticulum unfolded protein response
GO:0007186 TAS:ProtIncPG-protein coupled receptor signaling pathway
GO:0006955 IBA:GO_CentralPimmune response
GO:0050930 IGI:UniProtKBPinduction of positive chemotaxis
GO:0006954 TAS:UniProtKBPinflammatory response
GO:0035556 IDA:UniProtKBPintracellular signal transduction
GO:0008285 TAS:ProtIncPnegative regulation of cell proliferation
GO:0045744 IDA:UniProtKBPnegative regulation of G-protein coupled receptor protein signaling pathway
GO:0042119 TAS:UniProtKBPneutrophil activation
GO:0030593 IGI:UniProtKBPneutrophil chemotaxis
GO:0090023 TAS:BHF-UCLPpositive regulation of neutrophil chemotaxis
GO:0031623 IDA:UniProtKBPreceptor internalization
GO:0030155 IDA:UniProtKBPregulation of cell adhesion
GO:0045091 IDA:UniProtKBPregulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0034976 IDA:UniProtKBPresponse to endoplasmic reticulum stress
GO:0002237 IDA:BHF-UCLPresponse to molecule of bacterial origin
GO:0007165 TAS:ProtIncPsignal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18355ATF4 activates genes
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_15344Chemokine receptors bind chemokines
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_19231G alpha (i) signalling events
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_17015Metabolism of proteins
REACT_14819Peptide ligand-binding receptors
REACT_18277PERK regulates gene expression
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
REACT_18356Unfolded Protein Response (UPR)
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