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MGP001618

UniProt Annotations

Entry Information
Gene Namechemokine (C-X-C motif) ligand 8
Protein EntryIL8_HUMAN
UniProt IDP10145
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P10145-1; Sequence=Displayed; Name=2; IsoId=P10145-2; Sequence=VSP_001058;
FunctionIL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. {ECO:0000269|PubMed:11978786, ECO:0000269|PubMed:2145175, ECO:0000269|PubMed:2212672}.
InductionBy ER stress in a DDIT3/CHOP-dependent manner. {ECO:0000269|PubMed:20829347}.
InteractionP25025:CXCR2; NbExp=2; IntAct=EBI-3917999, EBI-2835281;
PtmCitrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation. {ECO:0000269|PubMed:18710930, ECO:0000269|PubMed:19608678}.
PtmSeveral N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form. {ECO:0000269|PubMed:11023497, ECO:0000269|PubMed:11978786, ECO:0000269|PubMed:2145175, ECO:0000269|PubMed:2212672, ECO:0000269|PubMed:2523801, ECO:0000269|PubMed:2648135}.
SimilarityBelongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitHomodimer.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il8/";
Web ResourceName=Wikipedia; Note=Interleukin-8 entry; URL="http://en.wikipedia.org/wiki/Interleukin_8";
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