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MGP001622

Record overview

MGPD IDMGP001622
Gene ID3606
SpeciesHomo sapiens (Human)
Gene Nameinterleukin 18
Gene Symbol IL18
SynonymsIGIF; IL-18; IL-1g; IL1F4;
Alternate namesinterleukin-18; IFN-gamma-inducing factor; IL-1 gamma; iboctadekin; interleukin 18 (interferon-gamma-inducing factor); interleukin-1 gamma;
Chromosome11
Map Location11q22.2-q22.3
SummaryThe protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
OrthologsView orthologs and multiple alignments for IL18

Proteins

interleukin-18 isoform 1 proprotein
Refseq ID:NP_001553
Protein GI:4504653
UniProt ID:Q14116
mRNA ID:NM_001562
Length:193
RefSeq Status:
MAAEPVEDNCINFVAMKFIDNTLYFIAEDDENLESDYFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTI
SVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTVQNED
 
mat_peptide: 37..193
product: Interleukin-18
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q14116.1)
calculated_mol_wt: 18217
peptide sequence: 
YFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDII
FFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTVQNED
 
interleukin-18 isoform 2 proprotein
Refseq ID:NP_001230140
Protein GI:342349321
UniProt ID:Q14116
mRNA ID:NM_001243211
Length:189
RefSeq Status:
MAAEPVEDNCINFVAMKFIDNTLYFIENLESDYFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKC
EKISTLSCENKIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTVQNED
 
mat_peptide: 37..193
product: Interleukin-18
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q14116.1)
calculated_mol_wt: 18217
peptide sequence: 
YFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDII
FFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTVQNED

mat_peptide: 33..189
product: interleukin-18 isoform 2
calculated_mol_wt: 18217
peptide sequence: 
YFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDII
FFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTVQNED
 
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