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MGP001622

UniProt Annotations

Entry Information
Gene Nameinterleukin 18
Protein EntryIL18_HUMAN
UniProt IDQ14116
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14116-1; Sequence=Displayed; Name=2; Synonyms=Delta3pro-IL-18; IsoId=Q14116-2; Sequence=VSP_044934; Note=Expressed in ovarian carcinoma but undetectable in normal ovarian epithelial cells. Resistant to proteolytic activation by caspase-1 and -4.;
FunctionAugments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
InteractionQ13478:IL18R1; NbExp=2; IntAct=EBI-3910835, EBI-9817499;
PtmThe pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form. {ECO:0000269|PubMed:15326478}.
SimilarityBelongs to the IL-1 family. {ECO:0000305}.
Subcellular LocationSecreted.
Web ResourceName=Wikipedia; Note=Interleukin-1 entry; URL="http://en.wikipedia.org/wiki/Interleukin_1";
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