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MGP001623

Record overview

MGPD IDMGP001623
Gene ID3611
SpeciesHomo sapiens (Human)
Gene Nameintegrin-linked kinase
Gene Symbol ILK
SynonymsP59; ILK-1; ILK-2; p59ILK; HEL-S-28;
Alternate namesintegrin-linked protein kinase; 59 kDa serine/threonine-protein kinase; epididymis secretory protein Li 28; integrin-linked kinase-2;
Chromosome11
Map Location11p15.4
EC Number2.7.11.1
SummaryThis gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
OrthologsView orthologs and multiple alignments for ILK

Proteins

integrin-linked protein kinase isoform 1
Refseq ID:NP_004508
Protein GI:4758606
UniProt ID:Q13418
mRNA ID:NM_004517
Length:452
RefSeq Status:
MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHG
NVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNFLTKLN
ENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALD
MARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEI
GMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
 
integrin-linked protein kinase isoform 1
Refseq ID:NP_001014794
Protein GI:62420873
UniProt ID:Q13418
mRNA ID:NM_001014794
Length:452
RefSeq Status:
Protein sequence is identical to GI:4758606 (mRNA isoform)
 
integrin-linked protein kinase isoform 1
Refseq ID:NP_001014795
Protein GI:62420875
UniProt ID:Q13418
mRNA ID:NM_001014795
Length:452
RefSeq Status:
Protein sequence is identical to GI:4758606 (mRNA isoform)
 
integrin-linked protein kinase isoform 2
Refseq ID:NP_001265370
Protein GI:510785740
UniProt ID:Q13418
mRNA ID:NM_001278441
Length:391
RefSeq Status:
MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHG
NVPLHYACFWGQDQVAESGQRRWARISTVFHTRTHSGRGPPALGPLWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPP
APHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEAL
QKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
 
integrin-linked protein kinase isoform 3
Refseq ID:NP_001265371
Protein GI:510785742
UniProt ID:Q13418
mRNA ID:NM_001278442
Length:318
RefSeq Status:
MPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRD
FNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTAR
ISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPA
KRPKFDMIVPILEKMQDK
 
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