MGP Database

MGP001623

Ontology/Pathway Information

Entrez Gene ID	3611
Gene Name	integrin-linked kinase
Gene Symbol	ILK
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005911	IEA:Ensembl	C	cell-cell junction
GO:0030054	IDA:HPA	C	cell junction
GO:0043034	IEA:Ensembl	C	costamere
GO:0005737	IDA:HPA	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0043198	IEA:Ensembl	C	dendritic shaft
GO:0005925	IDA:UniProtKB	C	focal adhesion
GO:0030027	IEA:UniProtKB-SubCell	C	lamellipodium
GO:0016020	IDA:UniProtKB	C	membrane
GO:0043025	IEA:Ensembl	C	neuronal cell body
GO:0005654	IDA:HPA	C	nucleoplasm
GO:0005886	IEA:UniProtKB-SubCell	C	plasma membrane
GO:0043234	IEA:Ensembl	C	protein complex
GO:0030017	IEA:UniProtKB-SubCell	C	sarcomere
GO:0001725	IEA:Ensembl	C	stress fiber
GO:0043195	IEA:Ensembl	C	terminal bouton
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0019901	IPI:UniProtKB	F	protein kinase binding
GO:0004674	IDA:UniProtKB	F	protein serine/threonine kinase activity
GO:0004871	IEA:Ensembl	F	signal transducer activity
GO:0001658	IEA:Ensembl	P	branching involved in ureteric bud morphogenesis
GO:0007569	IEA:Ensembl	P	cell aging
GO:0007050	IEA:Ensembl	P	cell cycle arrest
GO:0034329	TAS:Reactome	P	cell junction assembly
GO:0007160	TAS:ProtInc	P	cell-matrix adhesion
GO:0008283	NAS:UniProtKB	P	cell proliferation
GO:0045197	IEA:Ensembl	P	establishment or maintenance of epithelial cell apical/basal polarity
GO:0043206	IEA:Ensembl	P	extracellular fibril organization
GO:0010761	IEA:Ensembl	P	fibroblast migration
GO:0007229	IDA:MGI	P	integrin-mediated signaling pathway
GO:0032288	IEA:Ensembl	P	myelin assembly
GO:0022011	IEA:Ensembl	P	myelination in peripheral nervous system
GO:0010667	IEA:Ensembl	P	negative regulation of cardiac muscle cell apoptotic process
GO:2000178	IEA:Ensembl	P	negative regulation of neural precursor cell proliferation
GO:0043524	IEA:Ensembl	P	negative regulation of neuron apoptotic process
GO:0006469	IEA:Ensembl	P	negative regulation of protein kinase activity
GO:0014912	IEA:Ensembl	P	negative regulation of smooth muscle cell migration
GO:0048662	IEA:Ensembl	P	negative regulation of smooth muscle cell proliferation
GO:0021675	IEA:Ensembl	P	nerve development
GO:0048812	IEA:Ensembl	P	neuron projection morphogenesis
GO:0018105	IEA:Ensembl	P	peptidyl-serine phosphorylation
GO:0070527	IMP:UniProtKB	P	platelet aggregation
GO:0045773	IEA:Ensembl	P	positive regulation of axon extension
GO:0030513	IEA:Ensembl	P	positive regulation of BMP signaling pathway
GO:0090263	IMP:UniProtKB	P	positive regulation of canonical Wnt signaling pathway
GO:0001954	IEA:Ensembl	P	positive regulation of cell-matrix adhesion
GO:0030335	IEA:Ensembl	P	positive regulation of cell migration
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:0050775	IEA:Ensembl	P	positive regulation of dendrite morphogenesis
GO:0043406	IEA:Ensembl	P	positive regulation of MAP kinase activity
GO:0045663	IEA:Ensembl	P	positive regulation of myoblast differentiation
GO:0045669	IEA:Ensembl	P	positive regulation of osteoblast differentiation
GO:0042327	IMP:UniProtKB	P	positive regulation of phosphorylation
GO:0051897	IEA:Ensembl	P	positive regulation of protein kinase B signaling
GO:0045893	IMP:UniProtKB	P	positive regulation of transcription, DNA-templated
GO:0051291	IEA:Ensembl	P	protein heterooligomerization
GO:0043491	IEA:Ensembl	P	protein kinase B signaling
GO:0006468	IDA:UniProtKB	P	protein phosphorylation
GO:0032956	IEA:Ensembl	P	regulation of actin cytoskeleton organization
GO:0034446	IMP:UniProtKB	P	substrate adhesion-dependent cell spreading

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_111155	Cell-Cell communication
REACT_20649	Cell-extracellular matrix interactions
REACT_20676	Cell junction organization
REACT_20617	Localization of the PINCH-ILK-PARVIN complex to focal adhesions