MGP Database

MGP001632

Ontology/Pathway Information

Entrez Gene ID	3627
Gene Name	chemokine (C-X-C motif) ligand 10
Gene Symbol	CXCL10
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0009897	IEA:Ensembl	C	external side of plasma membrane
GO:0005576	IDA:BHF-UCL	C	extracellular region
GO:0005615	IBA:GO_Central	C	extracellular space
GO:0008603	TAS:ProtInc	F	cAMP-dependent protein kinase regulator activity
GO:0008009	IDA:UniProtKB	F	chemokine activity
GO:0048248	IDA:UniProtKB	F	CXCR3 chemokine receptor binding
GO:0008201	IMP:UniProtKB	F	heparin binding
GO:0005102	TAS:ProtInc	F	receptor binding
GO:0008015	TAS:ProtInc	P	blood circulation
GO:0007267	TAS:ProtInc	P	cell-cell signaling
GO:0007166	TAS:ProtInc	P	cell surface receptor signaling pathway
GO:0034605	IEA:Ensembl	P	cellular response to heat
GO:0071222	IMP:MGI	P	cellular response to lipopolysaccharide
GO:0070098	IMP:UniProtKB	P	chemokine-mediated signaling pathway
GO:0006935	IDA:UniProtKB	P	chemotaxis
GO:0051607	IEA:Ensembl	P	defense response to virus
GO:0007186	IMP:UniProtKB	P	G-protein coupled receptor signaling pathway
GO:0006955	IBA:GO_Central	P	immune response
GO:0006954	TAS:ProtInc	P	inflammatory response
GO:0007517	TAS:ProtInc	P	muscle organ development
GO:0016525	IEA:Ensembl	P	negative regulation of angiogenesis
GO:0043950	IDA:UniProtKB	P	positive regulation of cAMP-mediated signaling
GO:0030816	IDA:UniProtKB	P	positive regulation of cAMP metabolic process
GO:0008284	TAS:ProtInc	P	positive regulation of cell proliferation
GO:0002690	IBA:GO_Central	P	positive regulation of leukocyte chemotaxis
GO:0051281	IDA:UniProtKB	P	positive regulation of release of sequestered calcium ion into cytosol
GO:2000406	IDA:MGI	P	positive regulation of T cell migration
GO:0045944	TAS:UniProtKB	P	positive regulation of transcription from RNA polymerase II promoter
GO:0009306	IEA:Ensembl	P	protein secretion
GO:0042127	IDA:UniProtKB	P	regulation of cell proliferation
GO:0045859	TAS:GOC	P	regulation of protein kinase activity
GO:0010996	IEA:Ensembl	P	response to auditory stimulus
GO:0009409	IEA:Ensembl	P	response to cold
GO:0010332	IEA:Ensembl	P	response to gamma radiation
GO:0033280	IEA:Ensembl	P	response to vitamin D
GO:0007165	TAS:ProtInc	P	signal transduction
GO:0010818	IMP:UniProtKB	P	T cell chemotaxis

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_15344	Chemokine receptors bind chemokines
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_19231	G alpha (i) signalling events
REACT_19184	GPCR downstream signaling
REACT_21340	GPCR ligand binding
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_14819	Peptide ligand-binding receptors
REACT_14797	Signaling by GPCR
REACT_111102	Signal Transduction