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MGP001632

UniProt Annotations

Entry Information
Gene Namechemokine (C-X-C motif) ligand 10
Protein EntryCXL10_HUMAN
UniProt IDP02778
SpeciesHuman
Comments
Comment typeDescription
FunctionChemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
InductionBy IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response.
InteractionP27487:DPP4; NbExp=2; IntAct=EBI-7815386, EBI-2871277;
Mass SpectrometryMass=8641.8; Method=Electrospray; Range=22-98; Evidence={ECO:0000269|PubMed:11559369};
PtmCXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes.
SimilarityBelongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.
Subcellular LocationSecreted.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CXCL10ID40218ch4q21.html";
Web ResourceName=Wikipedia; Note=CXCL10 entry; URL="http://en.wikipedia.org/wiki/CXCL10";
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