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MGP001658

Record overview

MGPD IDMGP001658
Gene ID3670
SpeciesHomo sapiens (Human)
Gene NameISL LIM homeobox 1
Gene Symbol ISL1
SynonymsIsl-1; ISLET1;
Alternate namesinsulin gene enhancer protein ISL-1; ISL1 transcription factor, LIM/homeodomain; islet-1;
Chromosome5
Map Location5q11.1
SummaryThis gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ISL1

Proteins

insulin gene enhancer protein ISL-1
Refseq ID:NP_002193
Protein GI:115387114
UniProt ID:P61371
mRNA ID:NM_002202
Length:349
RefSeq Status:
MGDMGDPPKKKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVY
HIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCY
AANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQQQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFALQ
SDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPDTPNSMVASPIEA
 
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