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MGP Database

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MGP001658

UniProt Annotations

Entry Information

Gene Name	ISL LIM homeobox 1
Protein Entry	ISL1_HUMAN
UniProt ID	P61371
Species	Human

Comments

Comment type	Description
Function	Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity). {ECO:0000250}.
Ptm	Phosphorylated. {ECO:0000250}.
Similarity	Contains 1 homeobox DNA-binding domain. {ECO:0000255\|PROSITE-ProRule:PRU00108}.
Similarity	Contains 2 LIM zinc-binding domains. {ECO:0000255\|PROSITE-ProRule:PRU00125}.
Subcellular Location	Nucleus.
Subunit	At neuronal promoters, displaces LDB1 from LHX3 LIM domain to form a ternary complex in which ISL1 contacts both LHX3 and LDB1. {ECO:0000250}.
Tissue Specificity	Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.