MGP Database

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MGP001658

Ontology/Pathway Information

Entrez Gene ID3670
Gene NameISL LIM homeobox 1
Gene Symbol ISL1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 NAS:BHF-UCLCcytoplasm
GO:0005739 IDA:HPACmitochondrion
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 NAS:BHF-UCLCnucleus
GO:0043425 IPI:BHF-UCLFbHLH transcription factor binding
GO:0003682 IEA:EnsemblFchromatin binding
GO:0001158 IDA:BHF-UCLFenhancer sequence-specific DNA binding
GO:0030331 ISS:BHF-UCLFestrogen receptor binding
GO:0016922 ISS:BHF-UCLFligand-dependent nuclear receptor binding
GO:0001102 IPI:BHF-UCLFRNA polymerase II activating transcription factor binding
GO:0001105 IDA:BHF-UCLFRNA polymerase II transcription coactivator activity
GO:0008270 IEA:InterProFzinc ion binding
GO:0060413 ISS:BHF-UCLPatrial septum morphogenesis
GO:0031103 IEA:EnsemblPaxon regeneration
GO:0060913 IDA:BHF-UCLPcardiac cell fate determination
GO:0060379 IEA:EnsemblPcardiac muscle cell myoblast differentiation
GO:0003215 ISS:BHF-UCLPcardiac right ventricle morphogenesis
GO:0071385 ISS:BHF-UCLPcellular response to glucocorticoid stimulus
GO:0003203 ISS:BHF-UCLPendocardial cushion morphogenesis
GO:0060384 ISS:BHF-UCLPinnervation
GO:0048762 ISS:BHF-UCLPmesenchymal cell differentiation
GO:0090090 IEA:EnsemblPnegative regulation of canonical Wnt signaling pathway
GO:0050728 ISS:BHF-UCLPnegative regulation of inflammatory response
GO:0033147 ISS:BHF-UCLPnegative regulation of intracellular estrogen receptor signaling pathway
GO:0043524 ISS:BHF-UCLPnegative regulation of neuron apoptotic process
GO:0045665 IEA:EnsemblPnegative regulation of neuron differentiation
GO:0090074 ISS:BHF-UCLPnegative regulation of protein homodimerization activity
GO:0000122 ISS:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0001755 IEA:EnsemblPneural crest cell migration
GO:0048665 ISS:BHF-UCLPneuron fate specification
GO:0003151 ISS:BHF-UCLPoutflow tract morphogenesis
GO:0003148 ISS:BHF-UCLPoutflow tract septum morphogenesis
GO:0031016 ISS:BHF-UCLPpancreas development
GO:0048936 ISS:BHF-UCLPperipheral nervous system neuron axonogenesis
GO:0060037 ISS:BHF-UCLPpharyngeal system development
GO:0021983 IEA:EnsemblPpituitary gland development
GO:0045766 ISS:BHF-UCLPpositive regulation of angiogenesis
GO:0008284 IEA:EnsemblPpositive regulation of cell proliferation
GO:0043388 IEA:EnsemblPpositive regulation of DNA binding
GO:0071657 ISS:BHF-UCLPpositive regulation of granulocyte colony-stimulating factor production
GO:0032725 ISS:BHF-UCLPpositive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032024 IC:BHF-UCLPpositive regulation of insulin secretion
GO:0032729 ISS:BHF-UCLPpositive regulation of interferon-gamma production
GO:0032735 ISS:BHF-UCLPpositive regulation of interleukin-12 production
GO:0032730 ISS:BHF-UCLPpositive regulation of interleukin-1 alpha production
GO:0032731 ISS:BHF-UCLPpositive regulation of interleukin-1 beta production
GO:0032755 ISS:BHF-UCLPpositive regulation of interleukin-6 production
GO:1901258 ISS:BHF-UCLPpositive regulation of macrophage colony-stimulating factor production
GO:0045944 ISS:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0032760 ISS:BHF-UCLPpositive regulation of tumor necrosis factor production
GO:0042517 IEA:EnsemblPpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0010575 ISS:BHF-UCLPpositive regulation vascular endothelial growth factor production
GO:0003266 IEA:EnsemblPregulation of secondary heart field cardioblast proliferation
GO:0031290 IEA:EnsemblPretinal ganglion cell axon guidance
GO:0003139 IMP:BHF-UCLPsecondary heart field specification
GO:0048880 ISS:BHF-UCLPsensory system development
GO:0021520 IEA:EnsemblPspinal cord motor neuron cell fate specification
GO:0021522 ISS:BHF-UCLPspinal cord motor neuron differentiation
GO:0021559 ISS:BHF-UCLPtrigeminal nerve development
GO:0055010 ISS:BHF-UCLPventricular cardiac muscle tissue morphogenesis
GO:0021524 IEA:EnsemblPvisceral motor neuron differentiation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_23974Incretin synthesis, secretion, and inactivation
REACT_17015Metabolism of proteins
REACT_160078Peptide hormone metabolism
REACT_23824Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
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