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MGP001892

Record overview

MGPD IDMGP001892
Gene ID4190
SpeciesHomo sapiens (Human)
Gene Namemalate dehydrogenase 1, NAD (soluble)
Gene Symbol MDH1
SynonymsMDHA; MOR2; MDH-s; HEL-S-32; MGC:1375;
Alternate namesmalate dehydrogenase, cytoplasmic; cytosolic malate dehydrogenase; diiodophenylpyruvate reductase; epididymis secretory protein Li 32; soluble malate dehydrogenase;
Chromosome2
Map Location2p13.3
EC Number1.1.1.37
SummaryMalate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
OrthologsView orthologs and multiple alignments for MDH1

Proteins

malate dehydrogenase, cytoplasmic isoform 1
Refseq ID:NP_001186040
Protein GI:312283701
UniProt ID:P40925
mRNA ID:NM_001199111
Length:352
RefSeq Status:
MRRCSYFPKDVTVFDKDDKSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLD
VAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVI
IWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPD
DLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
 
malate dehydrogenase, cytoplasmic isoform 2
Refseq ID:NP_005908
Protein GI:5174539
UniProt ID:P40925
mRNA ID:NM_005917
Length:334
RefSeq Status:
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKD
LLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKV
KLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFV
EGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
 
malate dehydrogenase, cytoplasmic isoform 3
Refseq ID:NP_001186041
Protein GI:312283703
UniProt ID:P40925
mRNA ID:NM_001199112
Length:245
RefSeq Status:
MPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSS
TQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFP
VVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
 
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