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MGP001892

UniProt Annotations

Entry Information
Gene Namemalate dehydrogenase 1, NAD (soluble)
Protein EntryMDHC_HUMAN
UniProt IDP40925
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P40925-1; Sequence=Displayed; Name=2; IsoId=P40925-2; Sequence=VSP_042661; Name=3; IsoId=P40925-3; Sequence=VSP_045847; Note=No experimental confirmation available.;
Catalytic Activity3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH. {ECO:0000269|PubMed:3052244}.
Catalytic Activity(S)-malate + NAD(+) = oxaloacetate + NADH. {ECO:0000269|PubMed:3052244}.
PtmAcetylation at Lys-118 dramatically enhances enzymatic activity and promotes adipogenic differentiation. {ECO:0000269|PubMed:19608861, ECO:0000269|PubMed:22693256, ECO:0000269|Ref.8}.
PtmISGylated. {ECO:0000269|PubMed:16139798}.
SimilarityBelongs to the LDH/MDH superfamily. MDH type 2 family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer.
Web ResourceName=Wikipedia; Note=Malate dehydrogenase entry; URL="http://en.wikipedia.org/wiki/Malate_dehydrogenase";
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