MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001893

Record overview

MGPD IDMGP001893
Gene ID4191
SpeciesHomo sapiens (Human)
Gene Namemalate dehydrogenase 2, NAD (mitochondrial)
Gene Symbol MDH2
SynonymsMDH; MOR1; M-MDH; MGC:3559;
Alternate namesmalate dehydrogenase, mitochondrial;
Chromosome7
Map Location7cen-q22
EC Number1.1.1.37
SummaryMalate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
OrthologsView orthologs and multiple alignments for MDH2

Proteins

malate dehydrogenase, mitochondrial isoform 1 precursor
Refseq ID:NP_005909
Protein GI:21735621
UniProt ID:P40926
mRNA ID:NM_005918
Length:338
RefSeq Status:
MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPA
GVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGH
AGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIE
KNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
 
transit_peptide: 1..24
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (P40926.3)
calculated_mol_wt: 2521
peptide sequence: 
MLSALARPASAALRRSFSTSAQNN

mat_peptide: 25..338
product: Malate dehydrogenase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P40926.3)
calculated_mol_wt: 33001
peptide sequence: 
AKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATL
TAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLT
ALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELK
ASIKKGEDFVKTLK
 
malate dehydrogenase, mitochondrial isoform 2 precursor
Refseq ID:NP_001269332
Protein GI:538919685
UniProt ID:P40926
mRNA ID:NM_001282403
Length:296
RefSeq Status:
MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPA
GVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKA
GAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
 
transit_peptide: 1..24
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (P40926.3)
calculated_mol_wt: 2521
peptide sequence: 
MLSALARPASAALRRSFSTSAQNN

mat_peptide: 25..338
product: Malate dehydrogenase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P40926.3)
calculated_mol_wt: 33001
peptide sequence: 
AKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATL
TAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLT
ALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELK
ASIKKGEDFVKTLK

transit_peptide: 1..24
calculated_mol_wt: 2521
peptide sequence: 
MLSALARPASAALRRSFSTSAQNN

mat_peptide: 25..296
product: malate dehydrogenase, mitochondrial isoform 2
calculated_mol_wt: 28372
peptide sequence: 
AKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATL
TAACAQHCPEAMICVIANPGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAM
NGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
 
malate dehydrogenase, mitochondrial isoform 3
Refseq ID:NP_001269333
Protein GI:538919948
UniProt ID:P40926
mRNA ID:NM_001282404
Length:231
RefSeq Status:
MTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIP
LISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGK
VSSFEEKMISDAIPELKASIKKGEDFVKTLK
 
transit_peptide: 1..24
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (P40926.3)
calculated_mol_wt: 2521
peptide sequence: 
MLSALARPASAALRRSFSTSAQNN

mat_peptide: 25..338
product: Malate dehydrogenase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P40926.3)
calculated_mol_wt: 33001
peptide sequence: 
AKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATL
TAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLT
ALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELK
ASIKKGEDFVKTLK
 
  logo