MGP Database

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MGP001893

UniProt Annotations

Entry Information
Gene Namemalate dehydrogenase 2, NAD (mitochondrial)
Protein EntryMDHM_HUMAN
UniProt IDP40926
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P40926-1; Sequence=Displayed; Name=2; IsoId=P40926-2; Sequence=VSP_055312; Note=No experimental confirmation available.;
Catalytic Activity(S)-malate + NAD(+) = oxaloacetate + NADH. {ECO:0000255|PROSITE-ProRule:PRU10004}.
Enzyme RegulationEnzyme activity is enhanced by acetylation. {ECO:0000269|PubMed:20167786}.
PtmAcetylation is enhanced by up to 67% after treatment either with trichostin A (TSA) or with nicotinamide (NAM) with the appearance of tri-and tetraacetylations. Glucose also increases acetylation by about 60% (By similarity). {ECO:0000250}.
SimilarityBelongs to the LDH/MDH superfamily. MDH type 1 family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix.
SubunitHomodimer. {ECO:0000269|Ref.12}.
Web ResourceName=Wikipedia; Note=Malate dehydrogenase entry; URL="http://en.wikipedia.org/wiki/Malate_dehydrogenase";
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