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MGP001896

Record overview

MGPD IDMGP001896
Gene ID4199
SpeciesHomo sapiens (Human)
Gene Namemalic enzyme 1, NADP(+)-dependent, cytosolic
Gene Symbol ME1
SynonymsMES; HUMNDME;
Alternate namesNADP-dependent malic enzyme; Malic enzyme, cytoplasmic; NADP-ME; malate dehydrogenase; malic enzyme 1, soluble; pyruvic-malic carboxylase;
Chromosome6
Map Location6q12
EC Number1.1.1.40
SummaryThis gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ME1

Proteins

NADP-dependent malic enzyme
Refseq ID:NP_002386
Protein GI:4505143
UniProt ID:P48163
mRNA ID:NM_002395
Length:572
RefSeq Status:
MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPI
VYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENE
ELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQ
GAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNER
PIIFALSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLY
PPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFVRSQMYSTDYDQILPDCYSWPEEVQKIQTKVDQ
 
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