MGP Database

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MGP001896

Ontology/Pathway Information

Entrez Gene ID4199
Gene Namemalic enzyme 1, NADP(+)-dependent, cytosolic
Gene Symbol ME1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 ISS:UniProtKBCcytosol
GO:0005739 IEA:EnsemblCmitochondrion
GO:0043531 TAS:UniProtKBFADP binding
GO:0009055 TAS:UniProtKBFelectron carrier activity
GO:0004471 IEA:InterProFmalate dehydrogenase (decarboxylating) (NAD+) activity
GO:0004473 IDA:UniProtKBFmalate dehydrogenase (decarboxylating) (NADP+) activity
GO:0004470 IDA:UniProtKBFmalic enzyme activity
GO:0030145 IDA:UniProtKBFmanganese ion binding
GO:0051287 TAS:UniProtKBFNAD binding
GO:0050661 TAS:UniProtKBFNADP binding
GO:0008948 IEA:UniProtKB-ECFoxaloacetate decarboxylase activity
GO:0005975 NAS:ProtIncPcarbohydrate metabolic process
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0006108 IDA:UniProtKBPmalate metabolic process
GO:0006741 TAS:UniProtKBPNADP biosynthetic process
GO:0051262 IEA:EnsemblPprotein tetramerization
GO:0009743 TAS:UniProtKBPresponse to carbohydrate
GO:0009725 ISS:UniProtKBPresponse to hormone
GO:0044281 TAS:ReactomePsmall molecule metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_116145PPARA activates gene expression
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
SMP Pathway Links
SMP IDDescription
SMP00196Leigh Syndrome
SMP00558Primary hyperoxaluria II, PH2
SMP00334Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
SMP00212Pyruvate Dehydrogenase Complex Deficiency
SMP00559Pyruvate kinase deficiency
SMP00060Pyruvate Metabolism
SMP00466Transfer of Acetyl Groups into Mitochondria
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