MGP Database

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MGP001896

UniProt Annotations

Entry Information
Gene Namemalic enzyme 1, NADP(+)-dependent, cytosolic
Protein EntryMAOX_HUMAN
UniProt IDP48163
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48163-1; Sequence=Displayed; Name=2; IsoId=P48163-2; Sequence=VSP_057051; Note=No experimental confirmation available.;
Catalytic ActivityOxaloacetate = pyruvate + CO(2).
Catalytic Activity(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Divalent metal cations. Prefers magnesium or manganese. {ECO:0000250};
SimilarityBelongs to the malic enzymes family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:8187880}.
SubunitHomotetramer.
Tissue SpecificityExpressed in all tissues tested including liver, placenta and white adipose tissue. {ECO:0000269|PubMed:7622060, ECO:0000269|PubMed:8187880}.
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=ME1";
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