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MGP001920

Record overview

MGPD IDMGP001920
Gene ID4257
SpeciesHomo sapiens (Human)
Gene Namemicrosomal glutathione S-transferase 1
Gene Symbol MGST1
SynonymsMGST; GST12; MGST-I;
Alternate namesmicrosomal glutathione S-transferase 1; glutathione S-transferase 12; microsomal GST-1; microsomal GST-I;
Chromosome12
Map Location12p12.3-p12.1
EC Number2.5.1.18
SummaryThe MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]
OrthologsView orthologs and multiple alignments for MGST1

Proteins

microsomal glutathione S-transferase 1 isoform a
Refseq ID:NP_665707
Protein GI:22035634
UniProt ID:P10620
mRNA ID:NM_145764
Length:155
RefSeq Status:
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAKKYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDP
STAILHFRLFVGARIYHTIAYLTPLPQPNRALSFFVGYGVTLSMAYRLLKSKLYL
 
microsomal glutathione S-transferase 1 isoform a
Refseq ID:NP_665735
Protein GI:22035638
UniProt ID:P10620
mRNA ID:NM_145792
Length:155
RefSeq Status:
Protein sequence is identical to GI:22035634 (mRNA isoform)
 
microsomal glutathione S-transferase 1 isoform a
Refseq ID:NP_665734
Protein GI:22035636
UniProt ID:P10620
mRNA ID:NM_145791
Length:155
RefSeq Status:
Protein sequence is identical to GI:22035634 (mRNA isoform)
 
microsomal glutathione S-transferase 1 isoform a
Refseq ID:NP_064696
Protein GI:9945306
UniProt ID:P10620
mRNA ID:NM_020300
Length:155
RefSeq Status:
Protein sequence is identical to GI:22035634 (mRNA isoform)
 
microsomal glutathione S-transferase 1 isoform a
Refseq ID:NP_001247440
Protein GI:386869519
UniProt ID:P10620
mRNA ID:NM_001260511
Length:155
RefSeq Status:
Protein sequence is identical to GI:22035634 (mRNA isoform)
 
microsomal glutathione S-transferase 1 isoform b
Refseq ID:NP_001247441
Protein GI:386869521
UniProt ID:P10620
mRNA ID:NM_001260512
Length:106
RefSeq Status:
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAKKYLRTDDRVERVRSHCKAVTISIFERQSQNGATNEVKSML
YRVQQL
 
microsomal glutathione S-transferase 1 isoform c
Refseq ID:NP_001254527
Protein GI:390125204
UniProt ID:P10620
mRNA ID:NM_001267598
Length:87
RefSeq Status:
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAKKYLRTDDRVERVRRIKQTLSIYLASSI
 
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