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MGP001920

UniProt Annotations

Entry Information
Gene Namemicrosomal glutathione S-transferase 1
Protein EntryMGST1_HUMAN
UniProt IDP10620
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P10620-1; Sequence=Displayed; Name=2; IsoId=P10620-2; Sequence=VSP_046160; Note=No experimental confirmation available.;
Catalytic ActivityRX + glutathione = HX + R-S-glutathione.
Enzyme RegulationCan be activated by reagents that attack Cys-50 sulfhydryl, such as N-ethylmaleimide. Activation also occurs via nitration of Tyr-93 by peroxynitrite (By similarity). {ECO:0000250}.
FunctionConjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.
InteractionQ8WX92:NELFB; NbExp=2; IntAct=EBI-2691601, EBI-347721;
PtmPeroxynitrite induces nitration at Tyr-93 which activates the enzyme. {ECO:0000250}.
SimilarityBelongs to the MAPEG family. {ECO:0000305}.
Subcellular LocationMicrosome {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
SubunitHomotrimer; The trimer binds only one molecule of glutathione. {ECO:0000250}.
Tissue SpecificityHighly expressed in liver.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mgst1/";
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